The San Francisco 49ers could be getting back a major piece of their defense this week, as safety Talanoa Hufanga practiced ...

Sunday, 4:25 p.m. EDT, FOX BetMGM NFL odds: 49ers by 7 1/2. Against the spread: 49ers 1-1; Rams 0-2. Series record: 49ers ...

The Rams have their work cut out for them in Week 3 but they have a chance to upset the 49ers if they win these 5 matchups ...

There are many questions surrounding the Charlotte 49ers going into this week’s game against a Big Ten opponent, Indiana.

San Francisco 49ers defensive coordinator Nick Sorensen, offensive line/run game coordinator Chris Foerster, and quarterback ...

Anyone who has followed it is way up. Now, the model has simulated Jets vs ... Here are several NFL odds and NFL betting ...

The San Francisco 49ers have Super Bowl aspirations, but they didn't look like a championship-caliber team in Sunday's 23-17 ...

Leonard Floyd registered his first sack as a member of the 49ers on Monday Night Football against the Aaron Rodgers and the ...

Brock Purdy will be in line to go from one the NFL's biggest bargains to a deal worth in excess of $50 million a year when he ...

Just keep in mind a loss last year in Minnesota was part of the 49ers’ path to the Super Bowl: Without Deebo Samuel and ...