UTSA founded its football program in 2011, so not much history exists between these two. The Longhorns and Roadrunners have played just once as Texas beat UTSA by 21 points in Austin in 2022. Jahdae Barron, who is now a senior defensive back for the Longhorns, scored on a 44-yard interception return in that 41-20 victory.

UTSA transfer edge Trey Moore will captain Texas for the first time against his old team. Moore transferred from San Antonio in the spring and played in both opening games as a Longhorn. Head coach Steve Sarkisian is expected to play around with his roster against the Roadrunners,

On October 21, 2021, it was announced that UTSA had joined the American Athletic Conference and would start participating as a conference member in 2023. Other members of the AAC include North Texas, Rice, Tulsa, Army, FIU, FAU and South Florida.